Egyptians beat the world to the invention of toothpaste and actually used wine as one of its major ingredients. The Romans, after much research and development, used human urine as the main ingredient in their toothpaste formulation. In fact, Roman toothpaste was so popular among Roman aristocracy that human urine was imported from Portugal. (If it sounds ludicrous that the Romans used urinary products as toothpaste, remember ammonia has lightening and brightening qualities and is the main chemical found in human urine).